Ancestry.com Continues to Be Best In Class for DNA Ancestry Ethnic Composition

I've been very kind to 23andme in the past because of it's easy-to-use interface and it's candor when it comes to disclosing the weaknesses in its algorithm.  Nothing was worse than the other testing companies representing to people that their ethnic calculators were accurate, only to discover that the science was really just a guess.  Many authors have written entire chapters in books (this one quite funny!) that discuss these concepts.

But as 23andme prepares for its exciting and certainly in-demand upcoming IPO, it needs an update.  It needs to offer X chromosome searching, for one example.  

 And it's DNA ancestry has been lapped now, twice, by Ancestry.com.  Ancestry.com, who we've been harsh on before, now features INCREDIBLY accurate DNA ancestry estimates.  To tell you how far they've come, so fast, it'd be like going from horse and buggy to the space shuttle.  Their new tool is that accurate.

One user wrote me who hired a genealogist to complete a full pedigree.  That's 64 ancestors!  That user has a complete 64 ancestor pedigree now, well-documented with church and family records.  Of her 64 ancestors, 62 come from northeast Bavaria in Germany, 1 comes from Sweden, and 1 from the Czech Republic.  In other words, she's 96.8% German, from the Bavarian forest, and she's about 1.56% Swedish and Czech.

She got her ancestry results from Ancestry.com, and would you believe it said she is 96% German, from the Bavarian forest, and 2% Swedish, 2% Eastern European?  I mean, WOW.  Impressive.  Doubly impressive because, as we've posted before and many of you know, German and French ancestry is the hardest to call.

23andme still says this woman is German, Italian, British, Northwest European, etc.  In other words, it's pretty far off.  It has a ways to go.

Kudos to Ancestry for getting best-in-class and for cracking the German ancestry code.  We give major kudos to Tim Sullivan and everyone there for their hard work to become the absolute best.

Media Starts to Gets Home DNA Testing for Ancestry Right -- Thank God!

Kristen V. Brown is back with an excellent piece for Bloomberg, on home DNA testing, that is remarkably astute for a piece in the popular media.  

It confirms much of what readers of this blog have seen posted here repeatedly.  It's so good, it's worth quoting at length:

DNA is great at identifying familial relationships like parents, grandparents, aunts, uncles and even second and third cousins. Beyond that, it gets fuzzy.

The genes that make you a superfast runner or that identify you as Irish are less well-studied. The accuracy of any one test depends on the data your DNA is being compared to. One 2009 journal article said consumer DNA tests were akin to horoscopes exploiting the human tendency to hunt for patterns in meaningless data.

So what does it mean when a test says I’m 25 percent Irish?

It’s a misconception that these tests can tell you where your DNA was in the past. 

If a test tells you that you’re 25 percent Irish, what it actually means is that you are genetically similar to other people who are a part of the reference data set of Irish DNA that the company has collected. 

Because each company uses a different algorithm and data set, your results may vary based on which company you use. 

In other words: Take all this with one very large pinch of salt!

Meanwhile, in Slate, appeared another excellent piece by John Edward Terrell.  Here's the quote for you to read for yourself:

Whatever the motivations, the current popularity of commercial genetic profiling worries me for two reasons. One is that these companies may be promising results they can’t actually deliver. 

The notion, for example, that our genes can be used to trace our personal ancestry far back into the past—say, to Genghis Khan, the Emperor Charlemagne, or one of the pharaohs of ancient Egypt—makes little statistical sense. You may disagree, but to me this comes across as selling something more akin to snake oil than science.

What worries me most, however, is that companies offering personal genetic testing customarily seem to report back to those sending along a sample of their spit that they are a mix of different “ethnicities.” This is more than simply statistical nonsense.

We are happy that the mainstream media is finally getting it right, instead of publishing starry eyed pop-sci nonsense about DNA tests.

Don't ever forget: if you come from Central Europe (France, Germany, Italy, or nearby countries), or if you come from a country where there are simply insufficient samples (much of the rest of the world), these DNA tests will wipe your heritage off the map, by telling you that you are something else.  Basically, they're most accurate at the Continental level, unless you happen to come from an island in Europe with massive amounts of people getting tested, i.e., the U.K.

Read This If You're Curious About Your MyHeritage Ethnicity Results And You're Italian

MyHeritage ethnicity estimates seem to be THE WORST of all the major testing companies.

We've received dozens of emails from people of 100% document Italian heritage where MyHeritage says they are 0% Italian.  We've received three screenshots, which we will not share due to privacy concerns.

Something is amiss.  These people showed us documented Italian heritage, 100% Italian cousins, and some were born in Italy.  They show up on MyHeritage as Sardinian, Middle Eastern, Spanish, West Asian -- anything BUT Italian!!!

MyHeritage ain't getting it done.  We would demand a refund kind readers.  It's OK to come close.  As we've noted, all ethnic calculators are pseudo-science.

But MyHeritage isn't hitting the dart board in the bar next door.

Ancestry DNA Issues Revised Ancestry Estimates, Finds that Germans Exist

Judy G. Russell, the Legal Genealogist, is out with a fantastic new post on AncestryDNA's new ethnicity estimate percentages.

As she wryly notes in the opening, she is delighted to find out that they have discovered that Germans exist.

We've wrote about this before, as have others.  The major testing sites -- some of which are run by people who seem hostile to Germans (America's biggest ethnic group) -- have written Germans off the map.  23andme is particularly bad at identifying German DNA.  They disclose it too, but they bury it in the fine print.

We have been repeatedly depressed by newbies, who know from good paper records that they are a quarter German (or Swiss, or French, or Austrian) say, "duh, gee, duh, this unscientific website tells me I am really 21.2% English wow gee duh am I adopted?"  NO!  The science isn't there yet.  As Judy Russell says, "it's not quite soup."

And it STILL isn't quite soup.  This post focuses on Germans, but the major testing services have an equal problem with Italians, another major American ethnic group.  Poor Italians who get tested often end up with anything but Italian.  (Spare me your pseudoscience on how Italy has been invaded.  EVERY country has been invaded.)  Italy is a long country with many peaks and valleys, and for much of its history was an exporter of population to surrounding areas.  The testing sites need more samples to identify all the different permutations of Italians.

Bottom line, as we've said before, and as every credible scientist says - DO NOT TRUST the ethnicity estimates of the testing services.

DNA Testing for Heritage and Ancestry Is, Simply Put, Inaccurate

You go to take a cholesterol test, and your doctor, very thorough, sends you to four different labs.  One reports your cholesterol is 200, one says it's 180, one says 150, and one says 130...

After a car accident, you get go to four different body shops for quotes.  One says your car's paint color is taupe; one says it's sea blue; one says its ocean blue; and one calls it sea green...

You whip out four different rulers to measure your foot.  One says it's 12 inches; one says its 6; one says 8; and one says 9...

In all of these scenarios, you would make two conclusions:

1.  These test results (or body shops, or labs, or measuring sticks) are not that scientific!

2.  At least three -- and likely all four -- of these results MUST be wrong.

These parables sum up the world of DNA testing for heritage or "admixture."

We've said it before, and we'll say it again.  But today, Kristen V. Brown, a writer for Gizmodo, published an excellent piece discussing the snake oil that Ancestry.com, 23andme, Gencove, FTDNA, and other labs are selling.

Simply put, these labs cannot tell your ancestry.  I repeat, they cannot tell your heritage, or racial or ethnic admixture.  The science just isn't there yet.  And it might never be.

Brown details how she got four different results from four labs.

She also alludes to, but doesn't state um, confidently enough, about the concept about being confident about your known results.

It's what I jokingly (and longwindedly) call the:

"I was born in a tiny isolated village in the Swiss Alps that has never been invaded.  I know my mom and dad, and there's a video of my birth.  I DNA tested them and they are my parents.  I DNA tested my grandparents too, and they are my grandparents.  There were no affairs and no invasions in my town.  I know my great grandparents too and I am their spitting image.  The church records state I am Swiss going back to 1400.  But HELP, this DNA testing service said I'm British.  Am I British?"  (Or Indian or French or Dutch or whatever) problem.

NO, dummy, you're Swiss...

I for one, always read the fine print.  23andme, for example, states clearly that it cannot spot German (or French) heritage 92% of the time!  Germans make up the LARGEST PLURALITY of Americans.  Americans make up the LARGEST MAJORITY of those getting DNA tests done.  Thus, and I only say this half facetiously: these companies are engaging in the virtual ethnic cleansing of ethnic groups, wiping them off the genetic map, with their statements on people's heritage percentages, that are simply inaccurate.  

And 23andme, is, as far as we can tell, the most accurate lab!

Anyway, kudos to Kristen V. Brown and the people she interviewed for explaining it in her Gizmodo piece.  We suggest reading it.

AND THE WINNER IS... (Comparing Admixture/Heritage Tests on Gedmatch)

Methodology:

• We ran exhaustive tests of several commercial and free DNA-testing labs and ethnicity calculators.  
• To test the sites, we used only individuals with well-documented, double confirmed, 100% known ancestry.  
• We tested multiple males from multiple lines to assure as much as humanly possible no extra-parental events (bastardy) occurred.  
• We even tested minor nobility with documented ties to geographic locales.  
• We used individuals who do not come from cities or places of cosmopolitanism (influx of foreigners).  
• We tested only people with all four grandparents from the same locale.  
• We tested multiple people from different countries in Europe.

As we've posted before, of the commercial labs, 23andme takes first prize, and Ancestry.com is the worst.  23andme provides the most conservative and accurate ethnic ancestry approximations.

We have also completed our testing of all of the ancestry composition tests available on GEDMATCH.  Below is a summary, the results, and the rankings.

• First of all, the specialty labs, Ethiohelix, Gedrosia DNA, puntDNAL, etc. do not even come close to being accurate, at least for individuals of European heritage.
• None of MDLP's tests passed our accuracy gauntlet and correctly called west European DNA.

1. The overall winner, and the clear winner of all the tools currently available on Gedmatch, is the Eurogenes K13 test.  It was pretty darn good at distinguishing DNA from various western European lands, for people of "purebred" ancestry.

2. Coming in second was Eurogenes EUtest K15 v2, which also had a pretty darn good record of accurate calls.

3. An honorable mention, and a close third, with accurate calls roughly as close to the second-place finisher, was Dodecad's K12b test.

• No other tests besides those three were even close to "often accurate."
• No tests, including those three, were much use for accurately calling the ancestry of European "mutts."  We found that the same tests that were accurate with individuals with 100% heritage from one country, were of limited value for serving as an oracle (predicting accurately) the ancestry of individuals of mixed European heritage.

How DNA Ancestry Testing Works and How Can I Know It's Accurate

When a commercial DNA testing site like Ancestry.com or 23andme or FTDNA tests your DNA, they do not know which snippet came from which of your parents.

For example, if at a given point (a gene, in popular parlance), you have a "C" from your dad and a "T" from you mom (meaning you have brown eyes, but carry the blue-eyes gene), the testing service doesn't know which "letter" came from which parent.

What they then do is try to guess, stringing your DNA out into small chunks or strings of letters.

They then compare these to DNA in their reference database.  23andme's reference database, which is one of the best, if not the best in the world, only has about 11,000 samples in it.  To represent the whole world!


So if you have ancestry from a big country (like France or Germany) or a country that has pockets of deep isolation (like Italy), the odds -- that they have someone from your corner of the country, or your little isolated craggy valley in some mountain chain -- are small.

They then compare the little strings of letters and come up with a likelihood that you have ancestry from one of those reference populations.

23andme has the most scientific test in the business, but it gets French/German/Belgian/Dutch/Swiss/Austrian/Luxembourgisch ancestry wrong 92% of the time.  It most often shows up as "generic Northwest European."  Similarly, 23andme -- the best in the business -- can't identify Italian ancestry 50% of the time.  It often shows up incorrectly as Middle Eastern or Generic Southern European.

The moral of this story is to be patient with the science.  It's not 100% there yet.

If you have documented ancestry from one region, trust your documents.

If you don't have any cousins from a pool you were identified as, then chances are it was a miscall.  (For example, if you have documented Italian ancestry, but it says you are 1/8 Middle Eastern or 1/8 Spanish), then unless you have a known great-grandparent that is 100% such, it's probably a miscall.  (This would mean your parent would test as 1/4, by the way).

Finally, there is a series problem with testing sites, particularly FTDNA's, with the issue of timing.  If you go back far enough, we are ALL Africans, right?  Yet a DNA test telling you that you were African would not be too useful.  Do they mean recently or in the past?

Similarly, as has been well-documented, most European ancestry can be broken down into 3 big chunks: ancient hunter gatherers (Ancient Western Europeans, most similar modern population = Lithuanians); ancient farmers (Ancient Near Easterners, most similar modern populations include Greeks, Sardinians, others); and ancient pastoralists/horse rearers (Ancient Eurasian Steppe Dwellers, most similar modern populations include Ukrainians). But the migrations were really, truly all over the place.

Ancient Near Easterners are NOT modern Near Easterners.  Ancient hunter gatherers in France are NOT the modern French, etc.

If a test tells you that you have some Near Eastern blood, it often is sensing this ancient signal.

It doesn't do you much good for them to say that 6000 years ago, you had some ancestry in the Near East.  Everyone did.